Senku is a brilliant, eccentric teenager with an unshakeable faith in the scientific method. While others might despair at the loss of modern technology, Senku sees the Stone World as a blank canvas. Starting with nothing but calcium carbonate and vinegar, he begins a systematic technological ascent recreating everything from antibiotics to electricity and cell phones. Alongside his loyal friend Taiju and a village of primitive humans, Senku faces off against the Empire of Might, led by Shishio Tsukasa, in a battle to decide the philosophical future of humanity.